Police seized over 4,000 illegal cannabis plants and 33 pounds of dried cannabis, worth more than $2 million, at a site on Highway 3 in Wainfleet.
The raid followed a Health Canada referral about unauthorized cultivation.
58-year-old Ruyin Chen of Mississauga and 35-yesr-old Sirikat Khumhueang of Mississauga face charges related to illegal cannabis production and distribution.
The investigation is ongoing.
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