Niagara Regional Police arrested two suspects Thursday after executing a search warrant near Welland and Louis Streets in Port Colborne.
The investigation, which began in December, targeted fentanyl distribution in the area.
Officers seized fentanyl valued at $252,400, 13.9 grams of suspected crystal meth, 602 oxycodone pills, $55,220 in cash, and two loaded Glock handguns.
40 year old Jeffrey Boston and 42 year old Misti Barron, both of Port Colborne, face multiple charges.
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